The Research Behind Our Bioregulators

Supports adrenal gland function and the body's natural response to physical and everyday stress.

1. Discovery of a stable tripeptide targeting the N-domain of CRF1 receptor2020 — Liapakis G, Karageorgos V, Andreadelis I, et al.
2. The involvement of Nek2 and Notch in the proliferation of rat adrenal cortex triggered by POMC-derived peptides2014 — de Mendonca POR, Costa IC, Lotfi CFP
3. Cholecystokinin tetrapeptide effects on HPA axis function and elevated plus maze behaviour in maternally separated and handled rats2005 — Greisen MH, Bolwig TG, Wortwein G

Supports the structural health and normal function of bladder tissue.

1. Bioregulatory therapy for overactive bladder2024 — Kuzmin IV
2. Nociceptin/Orphanin FQ and Urinary Bladder2019 — Angelico P, Barchielli, Lazzeri, Guerrini, Calo
3. Correction of age-related bladder function decrease with peptide geroprotector in women2013 — Gomberg VG, Ryzhak GA, Lyutov
4. Peptide geroprotector application for treatment of elderly and senile patients with prostatic hyperplasia2013 — Gomberg VG, Ryzhak GA, Liutov

Supports the health and flexibility of blood vessels and circulation throughout the body.

1. Peptide bioregulation in the treatment of atherosclerosis and prevention of restenosis of the arteries of the lower extremities2026 — Khavinson VKh et al.
2. Polypeptide vessel complex and its role in physiology function regulation in aging pathology2019 — Kuznik BI, Ryzhak GA, Khavinson VK
3. Effects of vascular peptide bioregulator on cerebral microcirculation of old hypertensive rats2017 — Khavinson VKh et al.
4. Molecular aspects of vasoprotective peptide KED activity during atherosclerosis and restenosis2016 — Kozlov KL, Bolotov II, Linkova NS, et al.
5. Molecular aspects of anti-atherosclerotic effects of short peptides2014 — Khavinson VKh, Lin'kova NS, et al.
6. Epigenetic aspects of peptidergic regulation of vascular endothelial cell proliferation during aging2014 — Khavinson VKh, Tarnovskaia SI, et al.
7. The efficacy of peptide bioregulators of vessels in lower limbs chronic arterial insufficiency2014 — Kozlov KL, et al.

Supports the body's natural blood cell production processes.

1. Myelosuppression Alleviation and Hematopoietic Regeneration by Tetrahedral-Framework Nucleic-Acid Nanostructures Functionalized with Osteogenic Growth Peptide2022 — Zhang T, Zhou M, Xiao D, et al.
2. Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides2020 — Ashapkin V, Khavinson V, Shilovsky G, Linkova N, Vanyushin B
3. A cytomorphological basis for the correction of radiation-induced immunodeficiencies and hematopoietic depression using thymus and bone marrow peptides1994 — Khmel'nitskii OK et al.
4. Regulation of function of stem cell precursors of granulo- and monocytopoiesis by thymic and bone marrow polypeptide factors1982 — Filev LV, Khavinson VKh, Morozov VG

Supports cartilage and joint tissue health and mobility.

1. TP8, A Novel Chondroinductive Peptide, Significantly Promoted Neo-Cartilage Repair without Activating Bone Formation2025 — Zhu M, Jiang S, Li X, et al.
2. Peptides for Targeting Chondrogenic Induction and Cartilage Regeneration in Osteoarthritis2024 — Liao HJ, Chen HT, Chang CH
3. Peptides of cartilage tissue: regulation of chondrocyte proliferation, geroprotection and prospects for use in osteoarthrosis2023 — Myakisheva SN, Linkova NS, Polyakova VO, Ryzhak GA
4. Peptide Regulation of Chondrogenic Stem Cell Differentiation2023 — Linkova N, Khavinson V, Diatlova A, Myakisheva S, Ryzhak G
5. Prospects for using peptide bioregulators for prevention and treatment of age-associated diseases of the musculoskeletal system2019 — Ryzhak GA, Popovich IG, Khavinson VKh
6. Effect of peptide regulators on the structural and functional status of bone tissue in ageing rats2007 — Povorozniuk VV, Khavinson VKh, Makogonchuk AV, Ryzhak GA, Kreslov EA, Gopkalova IV

Supports brain and central nervous system function, including cognitive clarity and stress resilience.

1. Transport of Biologically Active Ultrashort Peptides Using POT and LAT Carriers2022 — Khavinson V, Linkova N, Kozhevnikova E, Dyatlova A, Petukhov M
2. Neuroepigenetic Mechanisms of Action of Ultrashort Peptides in Alzheimer's Disease2022 — Ilina A, Khavinson V, Linkova N, Petukhov M
3. Neuroprotective action of Cortexin, Cerebrolysin and Actovegin in acute or chronic brain ischemia in rats2021 — Kurkin DV, Bakulin DA, Morkovin EI, et al.
4. Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer's Disease2021 — Khavinson V, Ilina A, Kraskovskaya N, et al.
5. Peptide KED: Molecular-Genetic Aspects of Neurogenesis Regulation in Alzheimer's Disease2021 — Khavinson VK, Lin'kova NS, Umnov RS
6. Effect of short peptides on neuronal differentiation of stem cells2019 — Caputi S, Trubiani O, et al.
7. Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon2014 — Khavinson VKh et al.

Supports cardiovascular tissue health and the heart's natural function.

1. Senescence-Associated Secretory Phenotype of Cardiovascular System Cells and Inflammaging: Perspectives of Peptide Regulation2022 — Khavinson V, Linkova N, Dyatlova A, Kantemirova R, Kozlov K
2. Integrated multilayer omics reveals the genomic, proteomic, and metabolic influences of histidyl dipeptides on the heart2022 — Yan K, et al.
3. Histidine dipeptides are key regulators of excitation-contraction coupling in cardiac muscle: evidence from a novel CARNS1 knockout rat model2021 — Goncalves LS, Sales LP, Saito TR, et al.
4. Anti-apoptotic and anti-fibrotic effects of a potato-derived peptide in cardiac cells2018 — Marthandam Asokan S, Yang JY, Lin WT
5. Effect of amino acids and Cardiogen on the development of myocardial tissue culture from young and old rats2009 — Chalisova NI, Ryzhak AP, et al.
6. Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray2004 — Anisimov VN, Khavinson VKh et al.
7. Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology2002 — Khavinson VKh et al.

Supports kidney tissue health and the body's natural filtration processes.

1. Protection of kidney function and tissue integrity by pharmacologic use of natriuretic peptides and neprilysin inhibitors2021 — Brignone J, Assersen KB, Jensen M, et al.
2. The influence of peptides on the morphofunctional state of kidneys in old rats2018 — Zamorskii, Shchudrova, Zeleniuk, Linkova, Nichik, Khavinson
3. Nephroprotective Effect of EDL Peptide at Acute Injury of Kidneys of Different Genesis2017 — Zamorskii, Shchudrova, Linkova, Nichik, Khavinson
4. Peptides Restore Functional State of the Kidneys During Cisplatin-Induced Acute Renal Failure2015 — Zamorskii II, Shchudrova TS, Linkova NS, Nichik TE, Khavinson VKh
5. Peptide Regulation of Cells Renewal Processes in Kidney Tissue Cultures from Young and Old Animals2015 — Khavinson VKh et al.
6. Main mechanisms of rhabdomyolysis-caused kidney injury and their correction by organospecific peptides2015 — Khavinson VKh et al.
7. Tripeptides slow down aging process in renal cell culture2014 — Khavinson VKh, Tarnovskaia SI, Lin'kova NS, et al.

Supports liver tissue health and the body's natural detoxification processes.

1. The influence of polypeptide liver complex and tetrapeptide KEDA on organism physiological function in norm and age-related pathology2020 — Kuznik B, Khasanova, Ryzhak G, Mezsheriakova, Khavinson V
2. Effect of peptide Livagen on activity of digestive enzymes in gastrointestinal tract and non-digestive organs in rats of different ages2005 — Timofeeva NM, Khavinson VKh, Malinin, Nikitina, Egorova
3. Rhythm of protein synthesis in cultures of hepatocytes from rats of different ages. Norm and effect of the peptide Livagen2005 — Brodskii, Khavinson, Zolotarev, et al.
4. Functional morphology of an organotypic liver culture exposed to the peptide Livagen2002 — Riadnova, Filippov, Iuzhakov

Supports lung and respiratory tissue health.

1. An FGF2-Derived Short Peptide Attenuates Bleomycin-Induced Pulmonary Fibrosis2025 — Wang M, Sun Y, Zhao Y, et al.
2. Small Peptide Derivatives Within the Carbohydrate Recognition Domain of SP-A2 Modulate Asthma Outcomes2022 — Francisco D, Wang Y, Marshall C, Conway M, Addison KJ, Billheimer D, Kimura H, Numata M, Chu HW, et al.
3. Peptides: Prospects for Use in the Treatment of COVID-192020 — Khavinson V, Linkova N, Dyatlova A, Kuznik B, Umnov R
4. Antiinflammatory and regenerative effect of peptide therapy in the model of obstructive lung pathology2018 — Kuzubova NA et al.
5. Modulating Effect of Peptide Therapy on the Morphofunctional State of Bronchial Epithelium in Rats with Obstructive Lung Pathology2015 — Kuzubova NA, Lebedeva ES, Dvorakovskaya IV, et al.
6. Peptide Regulation of Gene Expression and Protein Synthesis in Bronchial Epithelium2014 — Khavinson VK, Tendler SM, Vanyushin BF, Kasyanenko NA, Kvetnoy IM, Linkova NS, Ashapkin VV, Polyakova VO, Basharina VS, Bernadotte A
7. Effect of the Peptide Bronchogen (Ala-Asp-Glu-Leu) on DNA Thermostability2011 — Monaselidze JR, Khavinson VKh, Gorgoshidze MZ, Khachidze DG, Lomidze EM, Jokhadze TA, Lezhava TA

Supports muscle tissue health, recovery, and physical performance.

1. Self-transducible LRS-UNE-L peptide enhances muscle regeneration2022 — Baek MO, Cho HJ, Min DS, Choi CS, Yoon MS
2. Potential Relevance of Bioactive Peptides in Sports Nutrition2021 — Konig D, Kohl J, Jerger S, Centner C
3. The Influence of Specific Bioactive Collagen Peptides on Body Composition and Muscle Strength in Middle-Aged, Untrained Men: A RCT2021 — Zdzieblik D, Jendricke P, Oesser S, Gollhofer A, Konig D

Supports ovarian tissue health and the body's natural reproductive rhythm.

1. The novel peptide PFAP1 promotes primordial follicle activation by binding to MCM52023 — Zhang Y, Wang H, Zhu Y, et al.
2. Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro2022 — Yue X, Liu SL, Guo JN, et al.
3. Protective effect of small peptides from Periplaneta americana on cyclophosphamide-induced premature ovarian failure2022 — Wang Q, Si H, Fu R, et al.
4. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice2003 — Anisimov VN, Khavinson VKh, Popovich IG, et al.

Supports pancreatic tissue health and the body's natural blood sugar regulation.

1. Correction of impaired glucose tolerance using tetrapeptide (Pancragen) in old female rhesus monkeys2017 — Goncharova ND, Ivanova LG, Oganyan TE, Vengerin AA, Khavinson VKh
2. The tetrapeptide pankragen forte efficiency in elderly people with prediabetic state2017 — Goncharova ND, Ivanova LG, Oganyan TE, et al.
3. Impact of tetrapeptide pancragen on endocrine function of the pancreas in old monkeys2014 — Goncharova ND, Ivanova LG, Oganian TE, Vengerin AA, Khavinson VKh
4. Effects of pancragen on the differentiation of pancreatic cells during their ageing2013 — Khavinson VKh, Durnova AO, Polyakova VO, Tolibova GK, Linkova NS, Kvetnoy IM, Kvetnaia TV, Tarnovskaya SI
5. Tetrapeptide stimulates functional activity of the pancreatic cells in aging2013 — Khavinson VKh et al.
6. A pentadecapeptide fragment of islet neogenesis-associated protein increases beta-cell mass and reverses diabetes in C57BL/6J mice2004 — Rosenberg L, Lipsett M, Yoon JW, et al.

Supports parathyroid tissue health and the body's natural calcium balance.

1. A parathyroid hormone related supramolecular peptide for multi-functionalized osteoregeneration2024 — Hao Z, Feng Q, Wang Y, et al.
2. Short carboxyl terminal parathyroid hormone peptides modulate human parathyroid hormone signaling in mouse osteoblasts2021 — Kritmetapak K, Singh RJ, Craig TA, Hines JM, Kumar R
3. Parathyroid hormone-related peptide as a local regulator of vascular calcification. Its inhibitory action on in vitro calcification by bovine vascular smooth muscle cells1997 — Jono S, Nishizawa Y, Shioi A, Morii H

Supports pineal gland function, including the body's natural sleep-wake rhythm.

1. Overview of Epitalon: Highly Bioactive Pineal Tetrapeptide with Promising Properties2025 — Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł
2. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis2020 — Khavinson V, Linkova N, Kozhevnikova E, et al.
3. Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people2007 — Korkushko OV, Lapin BA, Goncharova ND, Khavinson VKh, et al.
4. Antioxidant properties of geroprotective peptides of the pineal gland2007 — Kozina LS, Arutjunyan AV, Khavinson VKh
5. Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas2005 — Goncharova ND, Vengerin AA, Khavinson VKh, Lapin BA
6. Peptide correction of age-related pineal disturbances in monkeys2003 — Khavinson VKh et al.

Supports prostate tissue health in men.

1. Influence of Adding Zinc Arginyl-Glycinate to Improve Efficacy of Bioregulatory Peptides of the Prostate Gland in Treatment of Patients with Impaired Sperm Parameters2022 — Rybalov MA, et al.
2. The use of bioregulatory peptides in the treatment of men with benign prostatic hyperplasia and chronic prostatitis2021 — Kuzmenko AV, Vinnik YY, Kuzmenko VV, Gyaurgiev TA
3. Polypeptide prostatilen in the treatment of patients with complicated prostatitis2004 — Boiko NI
4. Influence of prostatilen on smooth muscle organs functional activity in surgical patients1999 — Al'-Shukri SKh, et al.
5. The use of prostatilen in treating patients with chronic prostatitis1991 — Tkachuk VN, Gorbachev AG, Khavinson VKh

Supports retinal tissue health and visual function.

1. The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy2025 — Khavinson VKh et al.
2. Objective structural and functional monitoring of polypeptide retinal neuroprotective therapy in diabetic retinopathy2024 — Malakhova AI, Strakhov VV, Malakhova YA
3. Retinoprotective effects of Retinalamin studied in an experimental model of photochemical damage to rabbit retinas2021 — Suetov AA, Alekperov SI, Odinokaya MA, Kostina AA
4. Peptide bioregulators: delivery and efficacy2020 — Erichev VP, Lovpache DN, Yaremenko TV
5. Molecular-Physiological Aspects of Regulatory Effect of Peptide Retinoprotectors2019 — Khavinson V, Trofimova S, Trofimov A, Solomin I
6. Evaluation of therapeutic sensitivity of retinal ganglion cells to targeted peptide bioregulator in culture2019 — Avetisov SE, Erichev VP, et al.
7. Peptidergic regulation of differentiation of embryonic retinal cells2013 — Khavinson VKh, Pronyaeva VE, Linkova NS, Trofimova SV
8. Effects of peptides on proliferative activity of retinal and pigmented epithelial cells2003 — Khavinson VKh et al.

Supports stomach tissue health and normal digestive function.

1. Peptides in the Treatment of Gastric Ulcer2024 — Kalnitsky et al.
2. Inflammation promotes stomach epithelial defense by stimulating the secretion of antimicrobial peptides in the mucus2024 — Vllahu et al.
3. Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: protection against alcohol-induced gastric mucosal injury2022 — Lu S, Kong S, Wang Y, Hu Z, Zhang L, Liao M
4. Lectinocytochemical study of rat stomach mucosa under conditions of COX-1/-2 blockage and pretreatment with H-Glu-Asp-Gly-OH2020 — Nasadyuk, Sogomonyan, Yashchenko, Sklyarov
5. Protective Effects of Wheat Peptides against Ethanol-Induced Gastric Mucosal Lesions in Rats2020 — Yu L, Li R, Liu W, et al.
6. Regulating effect of epithalone on gastric endocrine cells in pinealectomized rats2001 — Khavinson VKh et al.

Supports testicular tissue health and natural male reproductive function.

1. Bioactive Peptide C248 of PRDX4 Ameliorates the Function of Testicular Leydig Cells via Mitochondrial Protection2025 — Wei N, Yuan S, Gao L, et al.
2. Oral administration of VDAC1-derived small molecule peptides increases circulating testosterone levels in male rats2023 — Martinez-Arguelles DB, Nedow JW, Gukasyan HJ, Papadopoulos V
3. Testicular peptides and their endocrine and paracrine functions1984 — Steinberger A, Dighe RR, Diaz J

Supports thymus tissue health and the body's natural immune function.

1. The Influence of KE and EW Dipeptides in the Composition of the Thymalin Drug on Gene Expression and Protein Synthesis Involved in the Pathogenesis of COVID-192023 — Linkova N, Khavinson V, et al.
2. Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line2022 — Avolio F, Martinotti S, Khavinson VK, et al.
3. Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells2020 — Khavinson VK, Linkova NS, et al.
4. Peptidergic regulation of thymocyte differentiation, proliferation, and apoptosis during aging of the thymus2012 — Khavinson VKh et al.
5. Expression of argyrophilic proteins in the nucleolar organizer regions of human thymocytes and thymic epitheliocytes under conditions of coculturing with vilon and epithalon peptides2004 — Khavinson VKh et al.
6. Peptides of pineal gland and thymus prolong human life2003 — Khavinson VKh, Morozov VG

Supports thyroid tissue health and the body's natural metabolic balance.

1. Peptide Therapies in Thyroid Health: Emerging Applications in Endocrine and Immune Modulation2026 — Mazza AD
2. Therapeutic Effects of Short Cyclic and Combined Epitope Peptides in a Long-Term Model of Graves' Disease and Orbitopathy2019 — Fassbender J, Holthoff HP, Li Z, Ungerer M
3. Intranasal and Intramuscular Administration of Lysine-Palmitoylated Peptide 612-627 of TSH Receptor Increases the Level of Thyroid Hormones in Rats2015 — Derkach KV, Shpakova EA, Titov AK, Shpakov AO
4. Effects of peptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on hormonal activity and structure of the thyroid gland in hypophysectomized young chickens and old hens2011 — Khavinson VKh et al.
5. Effect of tetrapeptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on the structure and function of the thyroid gland in neonatally hypophysectomized chickens2008 — Khavinson VKh et al.
6. Peptide bioregulator efficacy in the correction of reduced thyroid gland function in the residents of Magadan Region2005 — Gorbachev AL, Lugovaia EA, Ryzhak GA, Khavinson VKh